Fig.1 MBP69-88 induced EAE model in Lewis. (A) body weight. (B) clinical score. (C) H&E and LFB staining of spleen tissue. (D) histological score. (E) LFB score.
Fig.1 MOG1-125 induced EAE model in C57BL/6. (A) body weight (B) clinical score.
Fig.2 MOG1-125 induced EAE model in C57BL/6. (A) spleen index (B) lymph node index.
Fig.3 Immune cells events in lymph node of MOG1-125 induced EAE model in C57BL/6 .
Fig.4 MOG1-125 induced EAE model in C57BL/6. (A) serum mIgG (B) serum hMOG1-125 mIgG.
Fig.5 MOG1-125 induced EAE model in C57BL/6. (A) typical pathology image (B) HE score of spinal cord (C) LFB score of spinal cord.
Figure 1. MOG1-125-induced hCD3/hCD19 mouse EAE model and evaluation of the efficacy of the Anti-CD3/CD19 bispecific antibody. (A) Body weight; (B) Clinical score
Figure 2. MOG1-125-induced hCD3/hCD19 mouse EAE model and evaluation of the efficacy of the anti-CD3/CD19 bispecific antibody. (A) Spleen index; (B) Brain index.
Figure 3. MOG1-125-induced hCD3/hCD19 mouse EAE model and evaluation of the efficacy of the anti-CD3/CD19 bispecific antibody. Flow cytometric analysis of lymphocyte subsets in lymph nodes.
Fig1. body weight and clinical score of MOG35-55 induced EAE model in C57BL/6. (n=5)
Fig2. Typical EAE pathology and LFB demyelination pathology in MOG35-55-induced EAE model with histological scoring comparison and LFB scoring comparison. ***P < 0.001 vs G2.
