C3-KO
品系全名
C57BL/6Smoc-C3em1Smoc
目录号
NM-KO-191193
品系状态
活体
基因信息
基因名
C3
品系描述
敲除C3基因exon 2，建立C3基因敲除小鼠模型。曾有基因修饰致死报导，详情点击基因信息中的MGI ID。
应用领域：免疫相关
*使用本品系发表的文献需注明: C3-KO mice (Cat. NO. NM-KO-191193) were purchased from Shanghai Model Organisms Center, Inc..
疾病预测
补体成分 3 缺乏
Complement Component 3 Deficiency
Complement Component 3 Deficiency
验证数据
Fig. 1 Detection of C3 expression in thymus by RT-PCR (male mice for both groups).
Wild type: one band at 225 bp with primers F1/R1(mC3) and one band at 123 bp with primers F/R(mGapdh).
Homozygous: no band with primers F1/R1(mC3) and one band at 123 bp with primers F/R(mGapdh).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig. 2 Detection of mouse C3 expression in serum by ELISA. (1 male WT C57BL/6 mouse and 3 male HO C3-KO mice)
Abbr. HO, homozygous; WT, wild type; N.D. not detected.
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