Tmem119-2A-CreERT2
品系全名
C57BL/6Smoc-Tmem119em2(P2A-CreERT2)Smoc
目录号
NM-KI-200234
品系状态
活体
基因信息
基因名
Tmem119
品系描述
A P2A-CreERT2 expression cassette was knocked into the Tmem119 gene stop codon site.
应用领域：Cre tool mice
*使用本品系发表的文献需注明: Tmem119-2A-CreERT2 mice (Cat. NO. NM-KI-200234) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. Tmem119-CreERT2 mice effectively recombine a conditional allele in microglia.
A-B. Confocal micrograph showing tdTomato expression in IBA-positive microglia upon tamoxifen administration , Absence of tdTomato expression in untreated animals. C-D, Representative immunostaining for astrocytes (C, GFAP, green), and neurons (D, NeuN, green) in tdTomato-expressing microglia of Tmem119-CreERT2+/−; Rosa26 tdTomato+/− mice.
发表文献
你也可能感兴趣
Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
查看
