Sox9-IRES-CreERT2
品系全名
C57BL/6Smoc-Sox9em(IRES-CreERT2-SV40pA)Smoc
目录号
NM-KI-204996
品系状态
活体
基因信息
基因名
Sox9
品系描述
验证数据

Fig. 1 CreERT2-mediated recombination in the heart of Sox9CreERT2/+;R26tdtomato/+ mouse. TdTomato can be detected in the heart of Sox9CreERT2/+;R26tdtomato/+ mouse. (Documented in the following reference.)

Fig. 2 CreERT2-mediated recombination in the heart of Sox9CreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in some cells of ventricle and atria derived from Sox9CreERT2 /+; Rosa26tdTomato/+ mouse after tamoxifen treatment.

Fig. 3 CreERT2-mediated recombination in the hair follicles of Sox9CreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the hair follicles and epidermis derived from Sox9CreERT2 /+; Rosa26tdTomato/+ mouse.

Fig. 4 CreERT2-mediated recombination in the liver of Sox9CreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the liver of Sox9CreERT2 /+; Rosa26tdTomato/+ mouse.

Fig. 5 Detection of tdTomato(red) in various tissues of Sox9CreERT2/+; Rosa26tdTomato/+ mice. CreERT2 mediated recombination can be detected in the heart, hair follicles and epidermis. Tdtomato expression can be also detected in individual cells derived from liver, brain, pituitary gland, retina, stomach, large intestine, small intestine, lung, submandibular gland, kidney, pancreas, spleen, thymus and ovary, except for brown fat tissue and muscle. (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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