Oprk1-2A-Cre

2A-Cre expression cassette was knocked into the Oprk1 gene stop codon site. Oprk1 (opioid receptor, kappa 1) encodes opioid receptor which was expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids.

Fig. 1 Cre-mediated recombination in the brain of Oprk1^Cre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the brain of Oprk1^Cre/+; Rosa26^tdTomato/+ mouse.

Fig. 2 Detection of tdTomato(red) in various tissues of Oprk1^Cre/+; Rosa26^tdTomato/+ mice. Tdtomato was also expressed in some cells of the liver, stomach, intestine, colon, muscle, eyes, heart, spleen and lung. Tdtomato expression can not be observed in the salivary gland, brown fat and skin.(For more detailed information please contact our technical advisor.)