Nmu-2A-Cre

2A-Cre-WPRE-polyA expression cassette was knocked into the Nmu gene stop codon site. Nmu gene encodes a member of the neuromedin family of neuropeptides. The encoded protein plays a role in energy homeostasis and body temperature regulation. And the protein is homologous with human NMU, which is linked toobesity.

Fig. 1 Cre-mediated recombination in the intestine of Nmu^Cre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the submucosal plexus (red arrows) of Nmu^Cre/+; Rosa26^tdTomato/+ mouse.

Fig. 2 Cre-mediated recombination in the intestine of Nmu^Cre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the substantia nigra pars reticulate(SNR) of Nmu^Cre/+; Rosa26^tdTomato/+ mouse.

Fig. 3 Detection of tdTomato(red) in various tissues of Nmu^Cre/+; Rosa26^tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the heart, intestine, colon, pancreas, ovary, uterus, thymus, stomach. Tdtomato can also be detected in individual cells of the brown fat, kidney, lung, liver, muscle, salivary gland, skin and spleen. (For more detailed information please contact our technical advisor.)