Nkx3-1-IRES-Cre

A IRES-iCre expression cassette was knocked into the Nkx3-1 gene stop codon site. Nkx3-1 (NK3 homeobox 1) encodes prostate-specific homeodomain protein. The gene product is a key element in protecting prostate epithelial cells from DNA damage. This strain is useful for studying prostate.

Fig. 1 Cre-mediated recombination in the prostate of Nkx3-1^Cre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the atrium derived from Nkx3-1^Cre/+; Rosa26^tdTomato/+ mouse.

Fig. 2 Detection of tdTomato(red) in various tissues of Nkx3-1^Cre/+; Rosa26^tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the prostate, brain, liver, kidney, salivary gland, stomach, thymus, colon, muscle, pancreas, brown fat, intestine and in individual cells of the spleen. (For more detailed information please contact our technical advisor.)