Cx3cr1-CreERT2
品系全名
C57BL/6Smoc-Cx3cr1em1(creERT2-WPRE-polyA)Smoc
目录号
NM-KI-200157
品系状态
精子冻存
基因信息
基因名
Cx3cr1
品系描述
A creERT2-WPRE-polyA expression cassette was knocked into the Cx3cr1 gene start codon site.
应用领域：Cre recombinase tool
*使用本品系发表的文献需注明: Cx3cr1-CreERT2 mice (Cat. NO. NM-KI-200157) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig. 1 CreERT2-mediated recombination in the brain of Cx3cr1CreERT2/+; Rosa26tdTomato/+ mouse.
Detection of tdTomato (red) in the brain of Cx3cr1CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. There is a significant leakage of cre expression in the brian in the absence of tamoxifen.
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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