Calb2-IRES-Cre

A IRES-iCre expression cassette was knocked into the Calb2 gene stop codon site. Calb2 gene encodes calbindin 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. The protein plays a key role in the nervous system.

Fig. 1 Cre-mediated recombination in the pituitary gland of Calb2^Cre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the hippocampus, cortex, olfactory bulb and cerebellar purkinje cells of Calb2^Cre/+; Rosa26^tdTomato/+ mouse.

Fig. 2 Detection of tdTomato(red) in various tissues of  Calb2^Cre/+; Rosa26^tdTomato/+ mice. Tdtomato expression can be detected in the brain, heart, lung, liver, stomach, kidney, pancreas, intestine, testis, epididymis, spleen, esophagus, thymus and colon.  (For more detailed information please contact our technical advisor.)