Slc17a6-IRES-Cre

品系全名

C57BL/6Smoc-Slc17a6em1(IRES-iCre)Smoc

目录号

NM-KI-200087

品系状态

活体

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基因信息

基因名
Slc17a6

基因曾用名

DNPI; VGLUT2; 2900073D12Rik

NCBI ID

140919

MGI ID

2156052

Ensembl ID

ENSMUSG00000030500

Pubmed

Slc17a6

人类同源基因

SLC17A6

品系描述

A IRES-iCre expression cassette was knocked into the Slc17a6 gene stop codon site.
应用领域：Cre recombinase tool; The glutamate transporter 2 gene (Vglut2/Slc17a6) is expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

验证数据

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Fig. 1 Cre-mediated recombination in the brain of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, hippocampus and thalamus derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the retina of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of Slc17a6Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the cortex, hippocampus, striatum and thalamus. TdTomato can also be detected in individual cells of the retinal ganglion cell layer and extranet layer, pituitary gland, heart, kidney, testis, epididymis, brown fat, thymus, spleen, stomach, skeletal muscle, intestine, colon, salivary gland and pancreas islet. Tdtomato expression can not be observed in the lung, liver or skin. (For more detailed information please contact our technical advisor.)


发表文献

Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus–thalamus circuitry
来源杂志：PNAS

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