Cela1-2A-DreERT2
品系全名
C57BL/6Smoc-Cela1em1(2A-DreERT2)Smoc
目录号
NM-KI-190094
品系状态
胚胎冻存
基因信息
基因名
Cela1
品系描述
A 2A-DreERT2 expression cassette was knocked into the Cela1 gene stop codon site.
应用领域：Dre recombinase tool, pancreatic acinar cells
*使用本品系发表的文献需注明: Cela1-2A-DreERT2 mice (Cat. NO. NM-KI-190094) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig.1 DreERT2-mediated recombination in the pancreas of Gja1DreERT2/+；R26tdTomato/+ mouse. TdTomato (red) expression can be detected in the pancreas after tamoxifen treatment. α-amylase(green) is a digestive enzyme that is predominantly secreted by the acinar cells of the exocrine pancreas. (Documented in the following reference.)
发表文献
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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