Kank1-2A-DreERT2
品系全名
C57BL/6Smoc-Kank1em1(2A-DreERT2)Smoc
目录号
NM-KI-190040
品系状态
胚胎冻存
基因信息
基因名
Kank1
品系描述
A 2A-DreERT2 expression cassette was knocked into the Kank1 gene stop codon site.
应用领域：Dre recombinase tool
*使用本品系发表的文献需注明: Kank1-2A-DreERT2 mice (Cat. NO. NM-KI-190040) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig.1 DreERT2-mediated recombination in the heart of Kank1DreERT2/+；R26tdTomato/+ mouse. TdTomato (red) expression can be detected in the heart after tamoxifen treatment. Fabp4 (green) is the marker gene known to be expressed in the coronary vessel endothelial cells. (Documented in the following reference.)
发表文献
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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