Slc17a6-CreERT2
品系全名
C57BL/6Smoc-Slc17a6em2(CreERT2)Smoc
目录号
NM-KI-190011
品系状态
精子冻存
基因信息
基因名
Slc17a6
品系描述
This tamoxifen-inducible Slc17a6-CreERT2 tool mouse model was established by inserting a 2A-CreERT2-WPRE-polyA co-expression cassette into the stop codon of Slc17a6 gene.
应用领域：Tool Mice
*使用本品系发表的文献需注明: Slc17a6-CreERT2 mice (Cat. NO. NM-KI-190011) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. Expression Pattern of Tomato in Slc17a6-CreERT2 +/-;R26- tdTomato+/- mice.
CreERT2-mediated recombination in excitatory glutamatergic neuron cell bodies of Slc17a6-CreERT2+/-; R26-tdTomato+/- mice. Slc17a6-CreERT2 mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to glutamatergic neurons.
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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