Isl1-CreERT2
品系全名
C57BL/6Smoc-Isl1em1(CreERT2) Smoc
目录号
NM-KI-00013
品系状态
胚胎冻存
基因信息
基因名
Isl1
品系描述
CreERT2 was inserted at the start codon (ATG site). The KI mice have a tamoxifen-inducible cre-mediated recombination system.
应用领域：Cre recombinase tool
*使用本品系发表的文献需注明: Isl1-CreERT2 mice (Cat. NO. NM-KI-00013) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig. 1 CreERT2-mediated recombination in the heart of Isl1CreERT2/+；R26tdtomato/+ mouse embryo at E13.5. The Isl1+ cell lineage (tdTomato) mainly contributes to the right ventricle at E13.5 of Isl1CreERT2/+；R26tdtomato/+. Tamoxifen was induced at E8.0. (Documented in the following reference.)
发表文献
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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