Epcam-2A-CreERT2
品系全名
C57BL/6Smoc-Epcamem1(2A-CreERT2)Smoc
目录号
NM-KI-00084
品系状态
胚胎冻存
基因信息
基因名
Epcam
品系描述
An 2A-CreERT2 co-expression cassette is inserted before 3'UTR region of Epcam gene .
*使用本品系发表的文献需注明: Epcam-2A-CreERT2 mice (Cat. NO. NM-KI-00084) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1 CreERT2-mediated recombination in kidney cells of Epcam CreERT2+/-;R26 tdTomato+/- mice. Detection of tdTomato epifluorescence (red) and co-immunostaining for Epcam (green) in kidney cells of Epcam CreERT2+/- ;R26 tdTomato+/- mice.
Fig2 CreERT2-mediated recombination in liver of Epcam-CreERT2+/-;R26 tdTomato+/- mice.
Fig3 CreERT2-mediated recombination in small Intestines of Epcam-CreERT2+/-;R26 tdTomato+/- mice.
Fig4 CreERT2-mediated recombination in large Intestines of Epcam-CreERT2+/-;R26 tdTomato+/- mice.
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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