Nkx3-1-IRES-CreERT2

品系全名

C57BL/6Smoc-Nkx3-1em1(IRES-CreERT2)Smoc

目录号

NM-KI-200071

品系状态

胚胎冻存

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基因信息

基因名
Nkx3-1

基因曾用名

Bax; NKX3A; NKX3.1; Nkx-3.1; bagpipe

染色体位置

14

NCBI ID

18095

MGI ID

97352

Ensembl ID

ENSMUSG00000022061

Pubmed

Nkx3-1

人类同源基因

NKX3-1

品系描述

A IRES-CreERT2 expression cassette was knocked into the Nkx3-1 gene stop codon site.
应用领域：This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. This strain is useful in studying prostate.

验证数据

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Fig. 1 CreERT2-mediated recombination in the prostate of Nkx3-1CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the prostate lumen cells of Nkx3-1CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

image.png

Fig. 2 Detection of tdTomato(red) in various tissues of Nkx3-1CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. Tdtomato was expressed in the prostate and individual cells of kidney. TdTomato can not be detected in the brain, thymus, retina, lung, liver, stomach, salivary gland, pancreas, colon, intestine, spleen, skin, testis and epididymis. (For more detailed information please contact our technical advisor.)


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