hALB
品系全名
C57BL/6JSmo-Albtm3(hALB)Smoc
目录号
NM-HU-200003
品系状态
胚胎冻存
基因信息
基因名
ALB
品系描述
通过同源重组，将小鼠Alb基因进行人源化修饰。
验证数据
图1. ELISA检测ALB人源化小鼠血清中hALB的表达情况。结果显示ALB人源化纯合子小鼠血清中可以检测到hALB的表达。
Fig.2 Detection of human ALB(A) and mouse ALB(B) expression in serum of WT C57BL/6 mice and HO hALB mice by ELISA. Human ALB was exclusively detectable in HO hALB mice. Mouse ALB was exclusively detectable in WT C57BL/6 mice. Serum were collected from wild-type C57BL/6 mice (n=3, male, 7 weeks old) and HO hALB mice (n=3, male, 7 weeks old), and analyzed by ELISA with anti-hALB ELISA kit and anti-mALB ELISA kit.
Abbr. HO, homozygous; WT, wild type; N.D. not detected.
Fig.3 Detection of human ALB expression in serum by ELISA. Human ALB was exclusively detectable in HO hALB, HO/HO hALB/hFCRN(2) and HO hALB(2) mice. Serum were collected from wild-type C57BL/6 mice and HO hALB, HO/HO hALB/hFCRN(2) and HO hALB(2) mice, and analyzed by ELISA with anti-hALB ELISA kit.
Abbr. HO, homozygous; WT, wild type; N.D. not detected.
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