NOD SCID

品系全名

NOD.Cg-Prkdcscid/NifdcSmoc

目录号

SM-019

品系状态

活体

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品系描述

该品系为非肥胖糖尿病（NOD）小鼠背景携带Scid自发突变，NOD SCID小鼠不会发生糖尿病，缺乏T细胞和B细胞，同时具备固有免疫缺陷。NOD SCID小鼠适合移植的细胞系种类较裸鼠更多；适用于部分PDX模型的移植；自发胸腺淋巴瘤，寿命短（约为6-9个月），不适合长期实验。

验证数据

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Fig1. Body weight growth curve of NOD SCID (n=1046)

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Fig 2. Detection of serum antibody subclasses in NOD SCID mice (8-week old, male).

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Fig3. Complete deletion of T, B and NK cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of T, B and NK cells by FACS.

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Fig4. Complete deletion of Monocytes, macrophages and DC cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of Monocytes, macrophages and DC cells by FACS.

image.pngFig5. Pathological examination of various tissues in NOD SCID mice. Thymus was absent in NOD SCID mice, and no significant pathologic abnormalities were found in the other tissues examined (8-week old, A males, B females).

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Fig6. Subcutaneous xenograft tumor growth in NOD SCID. 

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Fig7. Blood routine tests in NOD SCID.

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Fig8. Blood biochemistry in NOD SCID.

Table 1. NOD SCID xenograft cell lines

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发表文献 9篇

1. An mRNA-encoded scFv antibody targeting the helix-α3 of HPV18 E7 oncoprotein as a novel antiviral strategy
发表年份：2026 来源杂志：mBio

2. Trifluridine/Tipiracil Exhibits Potent Antitumor Activity in Triple-Negative Breast Cancer by Targeting SKP2 and Inducing Cell Cycle Arrest and Apoptosis
发表年份：2025 来源杂志：Current Pharmaceutical Analysis

3. Necroptosis enhances ‘don’t eat me’ signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis
发表年份：2024 来源杂志：Nature Communications

4. Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple-Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1-Regulated Cholesterol Metabolism
发表年份：2024 来源杂志：Advanced Science

5. CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway
发表年份：2023 来源杂志：Cancer Communications

6. Fatty acids support the fitness and functionality of tumor resident CD8+ T cells by maintaining SCML4 expression
发表年份：2023 来源杂志：CANCER RESEARCH

7. Inhibition of Mitochondrial Biosynthesis Using a “Right-Side-Out” Membrane-Camouflaged Micelle to Facilitate the Therapeutic Effects of Shikonin on Triple-Negative Breast Cancer
发表年份：2022 来源杂志：Advanced Healthcare Materials

8. Long noncoding RNA LINC00467 facilitates the progression of acute myeloid leukemia by targeting the miR-339/SKI pathway
发表年份：2020 来源杂志：LEUKEMIA & LYMPHOMA

9. Cuprous oxide nanoparticle-inhibited melanoma progress by targeting melanoma stem cells
发表年份：2017 来源杂志：International Journal of Nanomedicine

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