Alb-2A-DTRGFP(M-NSG)
品系全名
NOD.Cg-PrkdcscidIl2rgem1Albem1(2A-DTRGFP)Smoc
目录号
NM-KI-215047
品系状态
活体
品系描述
鉴定报告
下载验证数据
Fig.1 Diphtheria Toxin-mediated liver injury model in Alb-2A-DTRGFP (M-NSG) mice.
(A) Gross photographs of the liver. (B) ALT and AST. (C) HE staining. Mice were intraperitoneally administered DT (2.5 ng/g) on Day 0. On Day 3, serum was collected to measure hepatic function indices, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Concurrently, gross photographs of the liver were taken to assess hepatic injury (n=1-2 females, 10 weeks old). Note: steatosis (↑), single-cell apoptosis (↑), sinusoidal congestion (↑), inflammatory cell infiltration (↑). Scale bar. 100 μm.
Abbr. HE, heterozygous; DT, Diphtheria Toxin.
你也可能感兴趣
Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
查看Cre-lox系统介绍及使用汇总
你一定听说过Cre-lox重组系统，无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点，如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统，可以在特定细胞、组织或整个生物体，甚至在特定时间点敲除或表达某个基因，实现对特定基因的时空特异性操作，这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。
查看
