h4-1BB(2)
品系全名
C57BL/6JSmo-Tnfrsf9tm2(TNFRSF9)Smoc
目录号
NM-HU-190077
品系状态
活体
基因信息
基因名
Tnfrsf9
品系描述
验证数据
图1 FACS检测CD137(4-1BB)人源化杂合子小鼠脾脏淋巴细胞活化后人源4-1BB 表达。
4-1BB人源化杂合子小鼠脾脏淋巴细胞经anti-CD3 和anti-CD28 刺激后收集细胞染色，FACS 检测人源4-1BB 表达。结果显示：4-1BB 人源化杂合子小鼠活化的CD4+和CD8+T淋巴细胞中均可以检测到人源4-1BB 的活跃表达。（数据来自冠科）
图2. 流式检测4-1BB(CD137)人源化纯合子小鼠脾脏中h4-1BB的表达。结果显示：4-1BB人源化纯合子小鼠脾脏CD8阳性T细胞中可以检测到h4-1BB的表达，符合预期。
图3. 4-1BB人源化小鼠模型4-1BB激动剂药物体内抗肿瘤效果。Human- 4-1BB激动剂药物Urelumab和Utomilumab能够显著抑制MC38肿瘤在4-1BB人源化小鼠体内的生长，证明4-1BB人源化小鼠可用于评估anti-human 4-1BB antibody。（与Crownbio合作完成）
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