HLA-A11.1/B2M(2)
品系全名
C57BL/6JSmo-B2mtm1(hB2M-linker-HLA-A*1101/H2-D1)Smoc
目录号
NM-HU-241354
品系状态
活体
基因信息
基因名
B2M
品系描述
验证数据
Fig.1 Expression analysis of hB2M and HLA-ABC on CD45+ cells in blood of HLA-A11.1/B2M humanized mice.
Leukocytes were collected from wild-type C57BL/6 mice(11 weeks old) and homozygous HLA-A11.1/B2M humanized mice(15.7 weeks old) , and analyzed by flow cytometry with anti-mB2M, anti-hB2M, anti-mH2D and anti-HLA-ABC. hB2M and HLA-ABC were exclusively detectable in HLA-A11.1/B2M humanized mice, whereas mB2M and mH2D were exclusively detectable in wild-type C57BL/6 mice.
Fig.2 Analysis of immune cell subpopulations in the blood (n=3 per group).
Leukocytes were collected from the blood of wild-type C57BL/6 mice (female, 8 weeks old; male, 9 weeks) and homozygous HLA-A11.1/B2M humanized mice (9 weeks old), and Flow cytometry analysis was performed to assess leukocyte subpopulations.
Abbr. WT, wild type; HO, homozygous.
Fig.3 Analysis of immune cell subpopulations in the spleen (n=3 per group).
Leukocytes were collected from the spleens of wild-type C57BL/6 mice (female, 8 weeks old; male, 9 weeks) and homozygous HLA-A11.1/B2M humanized mice (9 weeks old), and flow cytometry analysis was performed to assess leukocyte subpopulations.
Abbr. WT, wild type; HO, homozygous.
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