Prox1-IRES-CreERT2

品系全名

C57BL/6JSmo-Prox1em1(IRES-CreERT2-pA)Smoc

目录号

NM-KI-200119

品系状态

活体

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基因信息

基因名
Prox1

品系描述

将IRES-CreERT2-pA插入到小鼠Prox1基因终止密码子处。 Prox1编码一个转录因子(prospero 相关同源框 1),这是淋巴管形成和维持所必需的。Prox1-CreERT2小鼠与含有loxP侧翼序列的小鼠交配时,诱导后,Cre介导的重组将导致后代表达Cre的细胞中floxed序列的缺失。
应用领域:Cre工具鼠,淋巴管内皮细胞等区域

验证数据

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Fig1. CreERT2-mediated recombination in Dentate Gyrus of Prox1CreERT2/+;Rosa26tdTomato/+  mouse.image.png

Fig2. CreERT2-mediated recombination in Small intestine of Prox1CreERT2/+;Rosa26tdTomato/+ mouse. image.png

Fig3. Detection of tdTomato(red) in various tissues of Prox1CreERT2/+;Rosa26tdTomato/+ mice. Labeling was also observed in pituitary gland, retina, heart, thymus, stomach, lung, submandibular gland, muscle, ovary, spleen, pancreas and kidney. (For more information please contact: 400-728-0660.)


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