Foxn1-IRES-Cre

品系全名

C57BL/6JSmo-Foxn1em1(IRES-iCre)Smoc

目录号

NM-KI-200106

品系状态

活体

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基因信息

基因名
Foxn1

基因曾用名

nu; Whn; nude; Fkh19; Hfh11; HFH-11; D11Bhm185e

NCBI ID

15218

MGI ID

102949

Ensembl ID

ENSMUSG00000002057

Pubmed

Foxn1

人类同源基因

FOXN1

品系描述

将IRES-iCre插入到小鼠Foxn1基因终止密码子处。 Foxn1（forkhead box N1），由该基因编码的蛋白质是叉头家族或“翼状螺旋”转录因子的一部分，在发育过程、免疫系统调节、新陈代谢、癌症和衰老中都很重要。当与含有loxP位点侧翼序列的小鼠杂交时，cre介导的重组会导致胸腺上皮细胞和角化细胞侧翼区域的缺失。
应用领域：Cre工具鼠，胸腺上皮细胞和角质形成细胞等区域

验证数据

image.png

图 1 Foxn1Cre/+; Rosa26tdTomato/+小鼠胸腺中tdTomato的表达情况。

Foxn1Cre/+; Rosa26tdTomato/+双转基因鼠，可在小鼠胸腺中检测到tdTomato的表达。

image.png

图 2 Foxn1Cre/+; Rosa26tdTomato/+小鼠各组织中tdTomato的表达情况。TdTomato在胸腺、眼球、皮肤、胃和子宫中有部分细胞表达，而在大肠、肾、肺、胰腺的个别细胞中表达。不表达的组织有：大脑、肌肉、心、肝、卵巢、小肠、脾。（更多详细信息请联系我司技术顾问。）


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