Wap-IRES-Cre

品系全名

C57BL/6JSmo-Wapem1(IRES-Cre-WPRE-polyA)Smoc

目录号

NM-KI-200064

品系状态

活体

导出PDF

基因信息

基因名
Wap

品系描述

将IRES-Cre-WPRE-polyA插入到小鼠Wap基因终止密码子处。
应用领域:该小鼠在Wap基因座表达Cre重组酶。当Wap-IRES-Cre与报告小鼠繁殖,报告基因表达在成年雌鼠哺乳期的乳腺上皮细胞。可用于乳腺癌的研究。

验证数据

Wap-IRES-Cre-1.png

图 1  在WapCre/+; Rosa26tdTomato/+雌鼠乳腺中,tdTomato的表达情况。

 WapCre/+; Rosa26tdTomato/+ 双转基因鼠,可在成年哺乳期雌鼠乳腺上皮细胞中表达tdTomato。

Wap-IRES-Cre-2.png

图 2 WapCre/+; Rosa26tdTomato/+  小鼠各组织中tdTomato的表达情况。Cre酶的活性可以在唾液腺和哺乳期小鼠乳腺中检测到。未检测到表达的组织包括:脑、胸腺、垂体、心、肺、肝、胃、肾、胰腺、棕色脂肪、大肠、脾、睾丸和附睾、肌肉、皮肤。(更多详细信息请联系我司技术顾问。)


发表文献 1篇


你也可能感兴趣

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看

Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

查看

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

查看