S100a4-2A-CreERT2

品系全名

C57BL/6JSmo-S100a4em1(2A-CreERT2-WPRE-polyA)Smoc

目录号

NM-KI-200024

品系状态

精子冻存

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基因信息

基因名
S100a4

品系描述

将2A-CreERT2-WPRE-polyA共表达结构插入到小鼠S100a4基因终止密码子处。
应用领域:Cre工具鼠

验证数据

S100a4-CreERT2-1.png

Figure 1:S100a4CreERT2/+; Rosa26tdTomato/+ 小鼠胃部中的tdTomato表达情况。

S100a4CreERT2/+; Rosa26tdTomato/+双转基因鼠,可在胃部成纤维细胞中表达tdTomato。证明S100a4-CreERT2小鼠可以成为实现成纤维细胞特异性敲除或表达的工具鼠。

S100a4-CreERT2-2.png

Figure 2: Tamoxifen诱导后,S100a4CreERT2/+; Rosa26tdTomato/+ 小鼠各组织中tdTomato的表达情况。


发表文献 2篇

1. AEBP1 drives fibroblast-mediated T cell dysfunction in tumors
发表年份:2025 来源杂志:Nature Communications

2. Insulin-like growth factor 2 drives fibroblast-mediated tumor immunoevasion and confers resistance to immunotherapy
发表年份:2024 来源杂志:JOURNAL OF CLINICAL INVESTIGATION

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