Isl1-CreERT2

品系全名

C57BL/6JSmo-Isl1em1(CreERT2) Smoc

目录号

NM-KI-00013

品系状态

活体

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基因信息

基因名
Isl1

基因曾用名

-

NCBI ID

16392

MGI ID

101791

Ensembl ID

ENSMUSG00000042258

Pubmed

Isl1

人类同源基因

ISL1

品系描述

将CreERT2敲入小鼠内源Isl1(ISL1 transcription factor, LIM/homeodomain )基因ATG位置，构建可受Tamoxifen诱导的Isl1-Cre工具鼠。利用该小鼠，可在心脏和后肢祖细胞中敲除flox的目的基因。该品系杂合子小鼠可正常存活繁育；纯合子小鼠Isl1缺失会引发胚胎致死。
应用领域：心脏

验证数据

image.png

图1 Isl1CreERT2/+；R26tdtomato/+ 胚胎的心脏中可检测到tdTomato的表达。

在Isl1CreERT2/+；R26tdtomato/+双转基因鼠E8.0时注射tomoxifen，可在E13.5的双转基因鼠心脏中检测到tdTomato的表达。Isl+细胞主要分化为右心室细胞。(见参考文献)


发表文献 1篇

1. Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases
发表年份：2018-08-21 来源杂志：Circulation

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