Dppa3-IRES-Cre

品系全名

C57BL/6JSmo-Dppa3em1(IRES-Cre)Smoc

目录号

NM-KI-00040

品系状态

活体

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基因信息

基因名
Dppa3

品系描述

Dppa3-Cre又称Stella-cre,将IRES-Cre表达框插入到Dppa3基因3'UTR区域中。Dppa3基因在早期生殖细胞系及胚胎发育中表达,Dppa3-Cre可有效地在胚胎早期及生殖细胞系中发挥Cre重组酶活性。
应用领域:Dppa3是一种母体效应基因,在原始生殖细胞、卵母细胞、植入前胚胎和 ES 细胞中特异性表达, 在早期胚胎发育中具有重要作用。

验证数据

image.png

图 1 Dppa3Cre/+; Rosa26Zsgreen/+ 小鼠各组织中Zsgreen的表达情况。

Dppa3Cre/+; Rosa26Zsgreen/+双转基因鼠,可在小鼠脑、心脏、肺、颌下腺、唾液腺、胃、肾脏、胰腺、睾丸、附睾、大肠和脾脏中检测到Zsgreen的表达。(更多详细信息请联系我司技术顾问。)

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图 2 Dppa3Cre/+; Rosa26tdTomato/+小鼠E14.5胚胎中广泛表达tdTomato。


发表文献 16篇

1. The IL17REL gene encodes a decoy receptor of IL-17 family cytokines to control gut inflammation
发表年份:2026 来源杂志:NATURE IMMUNOLOGY

2. AMPKα2 signals amino acid insufficiency to inhibit protein synthesis
发表年份:2025 来源杂志:Cell Metabolism

3. Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance
发表年份:2024 来源杂志:Molecular Cancer

4. PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction
发表年份:2024 来源杂志:Autophagy

5. Exploring the Link Between Autophagy-Lysosomal Dysfunction and Early Heterotopic Ossification in Tendons
发表年份:2024 来源杂志:Advanced Science

6. A Novel Role for the Longevity-Associated Protein SLC39A11 as a Manganese Transporter
发表年份:2024 来源杂志:Research

7. PCK2 maintains intestinal homeostasis and prevents colitis by protecting antibody-secreting cells from oxidative stress
发表年份:2024 来源杂志:IMMUNOLOGY

8. Unmasking Chemokine-Inducing Specificity in Oligosaccharide Biomaterial to Promote Hair Growth
发表年份:2023 来源杂志:ADVANCED MATERIALS

9. A Human-Specific De Novo Gene Promotes Cortical Expansion and Folding
发表年份:2023 来源杂志:Advanced Science

10. In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation
发表年份:2023 来源杂志:GENOME BIOLOGY

11. Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors
发表年份:2022 来源杂志:Nature Communications

12. Estrogen receptor β activation inhibits colitis by promoting NLRP6-mediated autophagy
发表年份:2022 来源杂志:Cell Reports

13. The HIF-2α/PPARα pathway is essential for liraglutide-alleviated, lipid-induced hepatic steatosis
发表年份:2021 来源杂志:BIOMEDICINE & PHARMACOTHERAPY

14. Estrogen Receptor α Regulates Metabolic-Associated Fatty Liver Disease by Targeting NLRP3–GSDMD Axis-Mediated Hepatocyte Pyroptosis
发表年份:2021 来源杂志:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

15. Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy
发表年份:2019 来源杂志:Theranostics

16. Inhibition of SIRT1 in hippocampal CA1 ameliorates PTSD-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via NHLH2/MAO-A pathway
发表年份:2019 来源杂志:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

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