Cdh1-2A-DreERT2

品系全名

C57BL/6JSmo-Cdh1em3(2A-DreERT2)Smoc

目录号

NM-KI-190031

品系状态

精子冻存

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基因信息

基因名
Cdh1

基因曾用名

Um; UVO; Ecad; ARC-1; E-cad; L-CAM; AA960649

NCBI ID

12550

MGI ID

88354

Ensembl ID

ENSMUSG00000000303

Pubmed

Cdh1

人类同源基因

CDH1

品系描述

利用CRISPR基因编辑技术，将2A-DreERT2共表达结构插入到小鼠Cdh1基因终止密码子处。
应用领域：Dre工具鼠

验证数据

image.png

图1 Cdh1DreERT2/+；R26tdtomato/+ 小鼠肝脏中可检测到tdTomato的表达。

经Tamoxifen诱导，Cdh1DreERT2/+；R26tdtomato/+双转基因鼠，可在肝脏细胞中表达tdTomato(红色)。E-CAD(绿色)是上皮细胞标志蛋白，由Cdh1基因编码。(见参考文献)


发表文献 1篇

1. A Suite of New Dre-recombinase Drivers Markedly Expands the Ability to Perform Intersectional Genetic Targeting
发表年份：2021-02-09 来源杂志：CELL STEM CELL

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