Sftpc-IRES-CreERT2

品系全名

C57BL/6JSmo-Sftpcem(IRES-CreERT2)Smoc

目录号

NM-KI-18020

品系状态

活体

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基因信息

基因名
Sftpc

基因曾用名

SP5; SPC; SP-C; Sftp2; Bricd6; Sftp-2; pro-SpC

NCBI ID

20389

MGI ID

109517

Ensembl ID

ENSMUSG00000022097

Pubmed

Sftpc

人类同源基因

SFTPC

品系描述

利用CRISPR基因编辑技术，将IRES-CreERT2敲入到小鼠Sftpc基因3'UTR中，他莫昔芬诱导型Cre重组酶CreERT2受内源Sftpc基因启动子驱动。诱导后，在II型肺泡细胞中表达Cre活性。 *该品系CreERT2有泄露情况（详见验证数据），请根据研究目的进行选择。
应用领域：II型肺泡细胞Cre工具鼠

验证数据

屏幕截图 2024-04-24 102231.png

Fig1. Cre mediated recombination in lung of SftpcCreERT2/+;Rosa26tdTomato/+ mouse.

image.png

Fig2. Detection of tdTomato(red) in various tissues of SftpcCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: lung epithelial cells, testis interstitial cells, salivary glands, muscles. Tissues that unexpressed include brain, spinal cord, retina, heart, liver, brown fat, thymus, kidney, pancreas, large and small intestine, spleen, and skin.(2-months old, male) (For more detailed information please contact our technical advisor.) 

发表文献 2篇

1. Targeting sorting nexin 3 to treat pulmonary fibrosis by dual modulating Wnt/β-catenin signaling
发表年份：2026 来源杂志：Cell Death & Disease

2. METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury
发表年份：2023 来源杂志：Clinical and Translational Medicine

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