Ar-Flox

品系全名

B6;129S-Artm1(flox)Smoc

目录号

NM-CKO-00110

品系状态

活体

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基因信息

基因名
Ar

基因曾用名

Tfm; AW320017

NCBI ID

11835

MGI ID

88064

Ensembl ID

ENSMUSG00000046532

Pubmed

Ar

人类同源基因

AR

品系描述

loxp位点位于Ar基因2号外显子区域两侧。若与Cre品系小鼠交配的后代可在Cre酶表达的组织中条件性敲除该基因。对于研究雄激素不敏感综合征、肥胖、糖尿病、前列腺癌等具有重要意义。
应用领域：雄激素不敏感综合征、肥胖、糖尿病、前列腺癌等

疾病预测

2型糖尿病
Type 2 Diabetes Mellitus

近似模型的表型

MGI:5502687
注：该品系与Fabp4-cre工具鼠交配才可能获得预期表型

参考文献

McInnes KJ, Smith LB, Hunger NI, Saunders PT, Andrew R, Walker BR, Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis. Diabetes. 2012 May;61(5):1072-81

肥胖
Obesity

近似模型的表型

MGI:2681522
注：该品系与CMV-cre工具鼠交配才可能获得预期表型

参考文献

Matsumoto T, Takeyama K, Sato T, Kato S, Androgen receptor functions from reverse genetic models. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):95-9

前列腺癌
Prostate Cancer

近似模型的表型

MGI:5009703
注：该品系与Pten-Flox(NM-CKO-18004)和Pbsn-cre工具鼠交配才可能获得预期表型

参考文献

Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H, Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth. Cancer Cell. 2011 Jun 14;19(6):792-804

发表文献 2篇

1. Androgens drive sexual dimorphism in liver metastasis by promoting hepatic accumulation of neutrophils
发表年份：2022 来源杂志：Cell Reports

2. Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells
发表年份：2021-12-01 来源杂志：ENDOCRINOLOGY

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