Fas-KO(BALB/c)

品系全名

BALB/cJSmo-Fasem2Smoc

目录号

NM-KO-191206

品系状态

胚胎冻存

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基因信息

基因名
Fas

基因曾用名

lpr; APO1; APT1; CD95; TNFR6; Tnfrsf6; AI196731

NCBI ID

14102

MGI ID

95484

Ensembl ID

ENSMUSG00000024778

Pubmed

Fas

人类同源基因

FAS

品系描述

敲除Fas基因exon 2，建立Fas基因敲除小鼠模型。
应用领域：免疫相关

疾病预测

膜性肾小球肾炎
Membranous Glomerulonephritis

近似模型的表型

MGI:4943704
注：该品系需与Il27ra-KO(NM-KO-190496)交配才可能获得预期表型

参考文献

Shimizu S, Sugiyama N, Masutani K, Sadanaga A, Miyazaki Y, Inoue Y, Akahoshi M, Katafuchi R, Hirakata H, Harada M, Hamano S, Nakashima H, Yoshida H, Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J Immunol. 2005 Dec 1;175(11):7185-92

系统性红斑狼疮
Systemic Lupus Erythematosus

近似模型的表型

MGI:3665495
注：该品系需与Ccr2-KO(NM-KO-190018)交配才可能获得预期表型

参考文献

de Lema GP, Maier H, Franz TJ, Escribese M, Chilla S, Segerer S, Camarasa N, Schmid H, Banas B, Kalaydjiev S, Busch DH, Pfeffer K, Mampaso F, Schlondorff D, Luckow B, Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice. J Am Soc Nephrol. 2005 Dec;16(12):3592-601

系统性红斑狼疮
Systemic Lupus Erythematosus

近似模型的表型

MGI:3800222
注：该品系需与Tnfrsf9-KO(2)(NM-KO-210216)交配才可能获得预期表型

参考文献

Ohta A, Sekimoto M, Sato M, Koda T, Nishimura S, Iwakura Y, Sekikawa K, Nishimura T, Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen. J Immunol. 2000 Jul 15;165(2):956-61

系统性红斑狼疮
Systemic Lupus Erythematosus

近似模型的表型

MGI:5478500
注：该品系需与Tlr9-KO(NM-KO-190168)交配才可能获得预期表型

参考文献

Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ, Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity. 2006 Sep;25(3):417-28

自身免疫性淋巴增生综合征
Autoimmune Lymphoproliferative Syndrome

近似模型的表型

MGI:2450098

参考文献

Adachi M, SuematsuS, Suda T, Watanabe D, FukuyamaH, Ogasawara J, Tanaka T, Yoshida N, Nagata S, Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2131-6

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