C57BL/6

品系全名

C57BL/6

目录号

SM-001

品系状态

活体

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品系描述

是第一个完成基因组测序的小鼠品系,毛色为黑色,被认作"标准"的近交系,为许多突变基因提供遗传背景。具有品系稳定、易于繁殖,应激反应均一,试验结果精度高等特点。

验证数据

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图1.C57BL/6小鼠生长曲线(n=840)。

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图2.C57BL/6小鼠血常规检测。



发表文献 46篇

1. Spatially Defined DNA Origami Cell Engagers for T and Natural Killer Cell-Mediated Immune Modulation
发表年份:2026 来源杂志:ACS Nano

2. A novel whole cancer cell vaccine based on modified β-glucan elicits robust anti-tumor immunity
发表年份:2026 来源杂志:Theranostics

3. 3D-cultured hUC-MSC-derived exosomes as macrophage mediators to suppress cholestatic fibrosis in mice via miR-1291–mediated multi-targeted pathways
发表年份:2026 来源杂志:CHEMICAL ENGINEERING JOURNAL

4. Targeting senescent EGR1+ B cells enhances immunotherapy efficacy in esophageal squamous cell carcinoma
发表年份:2026 来源杂志:Cell Reports Medicine

5. Ganoderma lucidum polysaccharide ameliorates cancer cachexia with enhanced efficacy in aged group by reprogramming arginine metabolism to modulate Treg formation
发表年份:2026 来源杂志:CANCER LETTERS

6. Post-traumatic stress disorder impairs CD8+ T cell-dependent anti-tumor immune responses by downregulating thiamine
发表年份:2026 来源杂志:Cell Communication and Signaling

7. Long-term sucralose exposure accelerates ovarian aging via gut microbiota dysbiosis
发表年份:2026 来源杂志:npj Science of Food

8. Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells
发表年份:2026 来源杂志:Cell Chemical Biology

9. Glioma Cell Membrane–Coated CaCO3 Nanoparticles for Localized Postoperative Chemo–Calcium Overload Therapy to Prevent Glioma Recurrence
发表年份:2026 来源杂志:International Journal of Nanomedicine

10. Exposure to paraben in early gestational period: Impact on placental estrogen biosynthesis and fetal growth restriction
发表年份:2026 来源杂志:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

11. NOTCH3 attenuates cytotoxicity via RBPJ-dependent PVR upregulation to influence immunotherapy outcomes in colorectal cancer
发表年份:2026 来源杂志:Frontiers in Immunology

12. Botulinum Neurotoxin Type A1 Alleviates Bleomycin-induced Skin Fibrosis by Inhibiting PI3K-Akt Pathway and Associated Cell Cycle and Proliferation
发表年份:2026 来源杂志:JOURNAL OF INVESTIGATIVE DERMATOLOGY

13. Eupalinolide B ameliorates liver fibrosis by targeting PKCα to suppress the AKT/mTOR axis in hepatic stellate cells
发表年份:2026 来源杂志:JOURNAL OF ETHNOPHARMACOLOGY

14. GABA induces myokine irisin release from skeletal muscle
发表年份:2026 来源杂志:LIFE SCIENCES

15. ROS-responsive diselenide exosomes restores mitophagy to resolve sterile inflammation in liver IRI
发表年份:2026 来源杂志:EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

16. ACSL4 Inhibition by AS-252424 Protects Visual Function by Suppressing RGC Ferroptosis After Retinal Ischemia Reperfusion Injury
发表年份:2026 来源杂志:MOLECULAR NEUROBIOLOGY

17. Transcriptional Heterogeneity of Cardiac Remodeling Between Type 1 and Type 2 Diabetes
发表年份:2026 来源杂志:Biomedicines

18. Lycium barbarum Polysaccharide Alleviates Renal Damage in Mouse Sepsis by Regulating M1/M2 Macrophage Polarization
发表年份:2026 来源杂志:Food Science & Nutrition

19. Phenothiazine alleviates cisplatin-mediated acute kidney injury by inhibiting ferroptosis
发表年份:2026 来源杂志:CELL AND TISSUE RESEARCH

20. Loss of hepaCAM inhibits cholesterol biosynthesis and impairs learning and memory in mice
发表年份:2026 来源杂志:BRAIN RESEARCH

21. Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome
发表年份:2025 来源杂志:Signal Transduction and Targeted Therapy

22. Inhibiting Liver-Derived C3 Protein Rescues Anesthesia/Surgery-Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis
发表年份:2025 来源杂志:Advanced Science

23. High-Resolution Multiplexed Sequencing of Single-Cell Full-length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion
发表年份:2025 来源杂志:Advanced Science

24. Glycyrrhiza polysaccharide-adjuvanted liposomal vaccine potentiates tumor immunotherapy through lymph node-targeted modulation of the DC-T cell axis
发表年份:2025 来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

25. Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells
发表年份:2025 来源杂志:Cell Death & Disease

26. Extracellular vesicles for delivery of functional telomerase
发表年份:2025 来源杂志:Cell Communication and Signaling

27. An injectable cisplatin hydrogel effectively suppresses tumors while preserving anti-infective immunity
发表年份:2025 来源杂志:MATERIALS & DESIGN

28. The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue
发表年份:2025 来源杂志:npj Science of Food

29. Activated T cells degrade extracellular proteins to enhance effector functions
发表年份:2025 来源杂志:Cell Reports

30. Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis
发表年份:2025 来源杂志:Cell Reports

31. Therapeutic efficacy of Sanhuang Xiexin decoction on atopic dermatitis via suppressing STAT3 signaling
发表年份:2025 来源杂志:JOURNAL OF ETHNOPHARMACOLOGY

32. Sex-dimorphic reprogramming of fetal mouse brain development by maternal estradiol excess
发表年份:2025 来源杂志:Biology of Sex Differences

33. α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice
发表年份:2025 来源杂志:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

34. Therapeutic Efficacy and Mechanistic Insights of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Chemotherapy-Induced Oral Mucositis
发表年份:2025 来源杂志:JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

35. Integrating global burden of disease analysis and single-cell omics identifies ANTXR2 as a potential diagnostic biomarker for AML in China
发表年份:2025 来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY

36. Andrographolide inhibits the upregulation of SLC19A3 to block the adipogenic differentiation of adipose-derived stem cells
发表年份:2025 来源杂志:iScience

37. Optimization of thrombopoietin mimetic peptide fusion proteins with albumin-binding domain for enhanced bioactivity and extended half-life
发表年份:2025 来源杂志:Scientific Reports

38. Blockade of CD47 signaling improves ferroptosis of lung cancer cells via activating Nrf2/FPN signaling
发表年份:2025 来源杂志:CELLULAR SIGNALLING

39. Hepatic stellate cells shape the ECM-disorganized and immunosuppressive microenvironment via CCL11/CCR3 axis in lenvatinib-treated hepatocellular carcinoma
发表年份:2025 来源杂志:CELLULAR SIGNALLING

40. Optical characterization of ocular collagen microstructure and anisotropy in animal and human eyes
发表年份:2025 来源杂志:Biomedical Optics Express

41. Asiaticoside protects against PDF-induced peritoneal fibrosis via suppression of AhR/Nrf2-mediated MMT and oxidative stress
发表年份:2025 来源杂志:NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

42. A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury
发表年份:2025 来源杂志:RENAL FAILURE

43. USP18 promote tumor immune evasion in pancreatic cancer through enhancing autolysosome-mediated degradation of MHC-I
发表年份:2025 来源杂志:American Journal of Cancer Research

44. Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression
发表年份:2025 来源杂志:DIGESTIVE DISEASES AND SCIENCES

45. Protocol for co-culture of primary neurons and organotypic hippocampal brain slices from mice
发表年份:2025 来源杂志:STAR Protocols

46. Extending dual-targeting upper-limit in liposomal delivery of lithospermic acid B for Alzheimer's mitochondrial revitalization
发表年份:2024 来源杂志:JOURNAL OF CONTROLLED RELEASE

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