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Models

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文献

Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice

模式生物：小鼠 产品与服务：PLAG1 研究领域：Cancer

涎腺肿瘤 β-catenin

发表日期：2006-02-01 | 来源杂志：Int J Cancer

文献

FAF1 phosphorylation by AKT accumulates TGF-beta type II receptor and drives breast cancer metastasis

模式生物：小鼠 产品与服务：Faf1 研究领域：Breast cancer

TGF-β 肿瘤转移 抑癌因子 促癌因子 EIIa-Cre 广泛表达Cre

发表日期：2017-04-01 | 来源杂志：Nat Commun

文献

Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human...

模式生物：斑马鱼 产品与服务：- 研究领域：Drug screening and drug mechanism

raddeanin a 肿瘤血管生成 VEGFR 异种移植模型 结直肠肿瘤 海葵

发表日期：2015-01-01 | 来源杂志：Phytomedicine

文献

Deletion of HNF1alpha in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice

模式生物：小鼠 产品与服务：hnf1α 研究领域：Liver

脂质代谢 肝癌 肿瘤

发表日期：2017-07-01 | 来源杂志：FEBS Lett

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Drug Screening

drug screening high throughput screening for drug discovery

With a comprehensive model organisms service platform that generates the mouse, zebrafish and C. elegans models, Shanghai Model Organisms enables high-throughput drug screening as well as the evaluation and research on drug efficacy, thus accelerating drug development and achieving greater accuracy in the prediction of in vivo interactions.

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Disease Mouse Models (Non-genetically-engineered)

diseases mice diseases model non genetically modified organisms

Shanghai Model Organisms has established a library of typical mouse models of human diseases through surgery or drug induction, thereby providing useful animal models for the research on pathogenesis of related diseases, functional studies of genes or proteins in diseases, screening of disease drugs and evaluation of therapeutic effects, etc.

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Research on Diseases

genetics diseases studies diseases research diseases

Shanghai Model Organisms provides a professional R&D platform for genetically-engineered mouse, zebrafish and nematode models, a service platform for phenotyping, and a rich repository of disease mouse models to support your studies on disease genetics, pathogenesis, drug treatments, and more.

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Cancer Model

research on cancer cancer model mouse models of cancer

The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

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