Tcf7-2A-EGFP-2A-CreERT
品系全名
C57BL/6Smoc-Tcf7em1(T2A-EGFP-P2A-CreERT)Smoc
目录号
NM-KI-232120
品系状态
精子冻存
基因信息
基因名
Tcf7
品系描述
验证数据
Fig1. CreERT2 mediated recombination in Spleen of Tcf72A-EGFP-2A-CreERT2/+; Rosa26tdTomato/+ mouse.
Fig2. Detection of EGFP(green) and tdTomato(red) in various tissues of Tcf72A-EGFP-2A-CreERT2/+; Rosa26tdTomato/+ mouse.
After tamoxifen induction, tdTomato was expressed in the brain, kidney, spleen, lung, large intestine, small intestine, stomach, skin, reproductive system, thymus, and vagina. EGFP fluorescence was expressed in the brain, reproductive system, and thymus.
(41-days old, female) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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