Casp8-Flox

品系全名

C57BL/6JSmo-Casp8em1(flox)Smoc

目录号

NM-CKO-190003

品系状态

活体

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基因信息

基因名
Casp8

基因曾用名

MACH; Mch5; FLICE; CASP-8

染色体位置

1

NCBI ID

12370

MGI ID

1261423

Ensembl ID

ENSMUSG00000026029

Pubmed

Casp8

人类同源基因

CASP8

品系描述

flox Casp8基因exon4。可与组织特异性Cre工具鼠交配，在表达Cre酶的细胞中，条件性敲除Casp8基因。
应用领域：肿瘤研究，凋亡

疾病预测

特应性皮炎
Atopic Dermatitis

近似模型的表型

MGI:4888399
注：该品系与KRT14-cre工具鼠交配才可能获得预期表型

参考文献

Li C, Lasse S, Lee P, Nakasaki M, Chen SW, Yamasaki K, Gallo RL, Jamora C, Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22249-54

自身免疫性淋巴组织增生综合征 2B 型
Autoimmune Lymphoproliferative Syndrome Type 2B

近似模型的表型

MGI:2655731
注：该品系与Lck-cre工具鼠交配才可能获得预期表型

参考文献

Salmena L, Hakem R, Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. J Exp Med. 2005 Sep 19;202(6):727-32

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