Evaluating the Efficacy of Tumor-targeted Antibody in vivo
At present, cancer immunotherapy has been shown to be the most beneficial treatment for cancer patients. Cancer immunotherapy(also called immuno-oncology) refers to a new type of treatment that stimulates the activities of the immune system to specifically attack tumor cells. In 2013, Science Magazine recognized cancer immunotherapy as a "turning point in cancer treatment". In that year, cancer immunotherpay emerged amongst the top ten scientific breakthroughs. In recent years, cancer immunotherapy, such as immune checkpoint inhibitors, has achieved remarkable clinical results.
Shanghai Model Organisms is dedicated to providing "best-in-class" animal models for the development of immunotherapy and antibody therapeutics.
Repository of Immune-HU models
Since 2014, Shanghai Model Organisms has independently developed more than 200 humanized immune checkpoint mouse models (Immune-Hu models), in which mouse immune checkpoint genes were replaced by their human counterparts. In collaboration with our industry partners, our models have been functionally validated, demonstrating their utilities for the accessment of in vivo efficacy of immuno-oncology therapy.
View a complete list of Research-Ready humanized mouse models
To get more info on our product development pipeline, please contact us at service.us@modelorg.com.
热门文章
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
查看你一定听说过Cre-lox重组系统，无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点，如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统，可以在特定细胞、组织或整个生物体，甚至在特定时间点敲除或表达某个基因，实现对特定基因的时空特异性操作，这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。
查看
