Cdh5-2A-CreERT2

品系全名

C57BL/6JSmo-Cdh5em1(2A-CreERT2-WPRE-polyA)Smoc

目录号

NM-KI-200173

品系状态

活体

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基因信息

基因名
Cdh5

基因曾用名

7B4; Vec; VECD; Cd144; VEcad; VE-Cad; AA408225

NCBI ID

12562

MGI ID

105057

Ensembl ID

ENSMUSG00000031871

Pubmed

Cdh5

人类同源基因

CDH5

品系描述

将2A-CreERT2-WPRE-polyA插入到小鼠Cdh5基因终止密码子处。
应用领域：CDH5(血管内皮钙粘蛋白, VEC)，是在血管系统中表达。在谱系示踪实验中，VEC-Cre将标记内皮细胞和血细胞。

验证数据


image.png

图 1 Cdh5CreERT2/+; Rosa26tdTomato/+ 小鼠主动脉中tdTomato的表达情况。

经Tamoxifen诱导后，Cdh5CreERT2/+; Rosa26tdTomato/+ 双转基因鼠，可在小鼠动脉血管内皮细胞中检测到tdTomato的表达。

image.png

图 2 Cdh5CreERT2/+; Rosa26tdTomato/+ 小鼠脊髓中tdTomato的表达情况。

经Tamoxifen诱导后，Cdh5CreERT2/+; Rosa26tdTomato/+ 双转基因鼠，可在小鼠脊髓的内皮细胞中检测到tdTomato的表达。


image.png

图 3 Cdh5CreERT2/+; Rosa26tdTomato/+ 小鼠小脑中tdTomato的表达情况。

经Tamoxifen诱导后，Cdh5CreERT2/+; Rosa26tdTomato/+ 双转基因鼠，可在小鼠小脑部分细胞中检测到tdTomato的表达。

image.png

图 4 Cdh5CreERT2/+; Rosa26tdTomato/+ 小鼠各组织中tdTomato的表达。TdTomato的表达可在脑、垂体、眼球、心脏、肺、肝、胃、颌下腺、棕色脂肪、肾脏、胰腺、大肠和小肠、脾、胸腺、肌肉、睾丸和附睾中检测到，在皮肤表皮层未见表达。（更多详细信息请联系我司技术顾问。）


发表文献 7篇

1. CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2+ endothelial cells
发表年份：2026 来源杂志：Cell Reports Medicine

2. Hepatic hypertension on-a-chip identifies GPR116 as a hydrostatic pressure mechanosensor to regulate vascular injury in cirrhosis
发表年份：2025 来源杂志：Science Advances

3. Endothelial Cell Integrin α6 Regulates Vascular Remodeling Through the PI3K/Akt-eNOS-VEGFA Axis After Stroke
发表年份：2025 来源杂志：Neuroscience Bulletin

4. Astrocyte-Derived Extracellular Vesicular miR-143-3p Dampens Autophagic Degradation of Endothelial Adhesion Molecules and Promotes Neutrophil Transendothelial Migration after Acute Brain Injury
发表年份：2023 来源杂志：Advanced Science

5. Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts
发表年份：2023 来源杂志：Redox Biology

6. Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)–Dependent Vasodilation and Blood Pressure Homeostasis
发表年份：2023 来源杂志：ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

7. Type H vessel/platelet-derived growth factor receptor β+ perivascular cell disintegration is involved in vascular injury and bone loss in radiation-induced bone damage
发表年份：2023 来源杂志：CELL PROLIFERATION

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