hCCR8(BALB/c)(2)
品系全名
BALB/cJSmo-Ccr8tm(hCCR8)Smoc
目录号
NM-HU-220501
品系状态
胚胎冻存
基因信息
基因名
CCR8
品系描述
验证数据
Fig1. Detection of hCCR8 expression on spleen-derived activated T cells and Tregs in hCCR8 KI mice.
*Splenocytes were activated by anti-mCD3/CD28 antibody in vivo.
Fig2. In vivo antitumor responses of anti-hCCR8 alone in BALB/c hCCR8(v2) knockin mice engrafted with CT26 tumor.
(A) Mean tumor growth curves upon treatment; (B) In vivo antitumor response of anti-hCCR8 in hCCR8 (v2) mice bearing CT26 tumor; (C) Expression of hCCR8 in spleen in hCCR8 (v2) mice bearing CT26 tumor.
Fig3. In vivo antitumor responses of anti-hCCR8 alone or in combination with anti-CTLA-4 in BALB/c hCCR8(v2) knockin mice engrafted with CT26 tumor.
(A) Mean tumor growth curves upon treatment; (B) Individual tumor growth curves upon treatment; (C) In vivo antitumor response of anti-hCCR8 in hCCR8 (v2) mice bearing CT26 tumor.
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