Mrc1-2A-CreERT2
品系全名
C57BL/6Smoc-Mrc1em2(2A-CreERT2)Smoc
目录号
NM-KI-220031
品系状态
活体
基因信息
基因名
Mrc1
品系描述
验证数据

Fig 1. CreERT2-mediated recombination in liver of Mrc1CreERT2/+; Rosa26tdTomato/+ mice.

Fig 2. Detection of tdTomato (red) in various tissues of Mrc1CreERT2/+; Rosa26tdTomato/+ mice.
After tamoxifen induction, tdTomato was expressed in the large intestine, small intestine, liver, lungs, spleen, skin, thymus, and salivary glands. Low levels of expression were observed in the pancreas, ovaries, and kidneys. No obvious expression was detected in the brain, spinal cord, or stomach.
(111-day old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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