Notch3-R170C

品系全名

C57BL/6Smoc-Notch3em1(R170C)Smoc

目录号

NM-KI-200254

品系状态

活体

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基因信息

基因名
Notch3

基因曾用名

N3; hpbk; AW229011

NCBI ID

18131

MGI ID

99460

Ensembl ID

ENSMUSG00000038146

Pubmed

Notch3

人类同源基因

NOTCH3

品系描述

将Notch3中第170位氨基酸由R变为C，建立Notch3点突变小鼠模型。
应用领域：罕见病模型--遗传性多发脑梗死性痴呆。

疾病预测

遗传性多发脑梗死性痴呆
Cadasil 1

近似模型的表型

MGI:5462095

参考文献

Wallays G, et al., Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2881-8

发表文献

Gut microbes exacerbate systemic inflammation and behavior disorders in neurologic disease CADASIL
来源杂志：Microbiome

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