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Flt3-KO/hFLT3LG(M-NSG)

品系名：NOD.Cg-Prkdc^scidIl2rg^%dNOD.Cg-Prkdc^scidIl2rg^em1Flt3^em1SmocNOD.Cg-Prkdc^scidIl2rg^em1Flt3l^em1(hFLT3LG)
品系状态：活体 | 目录号：NM-XA-252200

The Flt3-KO(M-NSG) (NM-KO-234079) was crossed with hFLT3LG(M-NSG)(NM-HU-242455) to generate Flt3-KO(M-NSG)/hFLT3LG(M-NSG) mice.

Flt3-KO/hFLT3LG/hIL15-TgV1(M-NSG)

品系名：NOD.Cg-.CgPrkdc^scidIl2rg^em1Tg(hIL15 V1)Il2rg^%dNOD.Cg-Prkdc^scidIl2rg^em1Flt3^em1NOD.Cg-Prkdc^scidIl2rg^em1Flt3l^{em1(hFLT3LG)Smoc}
品系状态：在研 | 目录号：NM-XA-254114

The hIL15-TgV1(M-NSG) (NM-KI-220133) was crossed with Flt3-KO/hFLT3LG(M-NSG)(NM-XA-252200) to generate hIL15-TgV1(M-NSG)/Flt3-KO/hFLT3LG(M-NSG) mice.

BALB/c

品系名：BALB/cAnSmoc
品系状态：活体 | 目录号：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

KPC

品系名：C57BL/6Smoc-Trp53^em4(R172H)Kras^{em4(LSL-G12D)}Tg(Pdx1-cre)Smoc
品系状态：活体 | 目录号：NM-KI-210096
验证数据：有

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

What is an inbred strain?

inbreeding coefficient inbreeding depression FVB

New Service Launch: Mouse Bone Metastasis Cancer Model and Pain-Related Behavior Assessment!

Bone metastasis cancer model Pain-related behavior assessment Cancer-induced bone pain Bone cancer pain models Mouse bone metastasis model Animal models in cancer research Cancer research services Bone metastasis in mice Pain management in cancer

We are excited to announce that GenoBioTX has launched a new service featuring mouse bone metastasis cancer models and pain-related behavior assessment, designed to support cancer research and pain management effectively.

Development of Purification Process

Gene Knockout

gene knockout gene knockout technology knockout mice

Expedite your research with highly customizable, gene knockout mouse models that provide thorough insight into key genetic mechanisms.

Evaluating the Efficacy of Tumor-targeted Antibody in vivo

immunotherapy immune checkpoint immune checkpoint genes

As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.

IBD model