Tmem173-Flox

品系全名

B6;129S-Tmem173tm1(flox)Smoc

目录号

NM-CKO-00014

品系状态

活体

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品系描述

分别于3号外显子之前和5号外显子后插入loxp位点。若与Cre品系小鼠交配的后代可在Cre酶表达的组织中条件性敲除该基因。 去除neo基因状态活体。
应用领域:细胞凋亡、免疫应答等免疫系统相关研究

发表文献 8篇

1. Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis
发表年份:2024 来源杂志:Theranostics

2. Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury
发表年份:2023 来源杂志:Military Medical Research

3. Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury
发表年份:2023 来源杂志:Advanced Science

4. STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease
发表年份:2023 来源杂志:MOLECULAR THERAPY

5. Original research: Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation
发表年份:2023 来源杂志:Journal for ImmunoTherapy of Cancer

6. Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer-Autonomous DNA-Sensing Signaling Axis
发表年份:2022 来源杂志:Advanced Science

7. A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion
发表年份:2022 来源杂志:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

8. Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling
发表年份:2021 来源杂志:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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