Hfe-KO

品系全名

C57BL/6Smoc-Hfeem1Smoc

目录号

NM-KO-200987

品系状态

胚胎冻存

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基因信息

基因名
Hfe

基因曾用名

MR2

NCBI ID

15216

MGI ID

109191

Ensembl ID

ENSMUSG00000006611

Pubmed

Hfe

人类同源基因

HFE

品系描述

敲除Hfe基因exon 2-5，建立Hfe基因敲除小鼠模型。

疾病预测

1型血色素沉着症
Hemochromatosis Type 1

近似模型的表型

MGI:2655482

参考文献

Levy JE, Montross LK, Andrews NC, Genes that modify the hemochromatosis phenotype in mice [see comments]. J Clin Invest. 2000 May;105(9):1209-16

1型血色素沉着症
Hemochromatosis Type 1

近似模型的表型

MGI:3033465

参考文献

Tomatsu S, Orii KO, Fleming RE, Holden CC, Waheed A, Britton RS, Gutierrez MA, Velez-Castrillon S, Bacon BR, Sly WS, Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15788-93

发表文献 1篇

1. Establishment of transgenic mice carrying the gene of human nuclear receptor NR5A2 (hB1F)
发表年份：2003-06-01 来源杂志：World J Gastroenterol

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