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Models

为您找到相关结果约215个
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R26-CAG-LNL-CaMPARI

品系名：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LNL-CaMPARI)-NSmoc
品系状态：胚胎冻存 | 目录号：NM-KI-00090

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven CaMPARI gene. The targeted mutation was inserted into the Gt(ROSA)26Sor locus by homologous recombination.

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hIL15-TgV1(NMG)

品系名：NOD-PrkdcscidIl2rgem1Tg(hIL2 SP-hIL15)Smoc
品系状态：精子冻存 | 目录号：NM-KI-220133
验证数据：有

These transgenic mice carry human IL15.

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R26-CAG-2xKRAB-dCas9-IRES-EGFP

品系名：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Loxp-2xKRAB-dCas9-IRES-EGFP)Smoc
品系状态：活体 | 目录号：NM-KI-18007
验证数据：有

These mice harbor a CAG-LSL-2xKRAB-dCas9-IRES-EGFP-WPRE-pA conditional expression cassette in mouse Rosa26 loci via homologous recombination. This strain can be used in CRISPR mediated target gene transcriptional inhibition (CRISPRi). The loxp-stop-loxp cassette was deleted.

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R26-CAG-LSL-hTM6SF2*E167K-EGFP

品系名：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc
品系状态：胚胎冻存 | 目录号：NM-KI-200017

These mice harbor a SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

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R26-CAG-Luc-2A-EGFP

品系名：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Luc-EGFP)Smoc
品系状态：活体 | 目录号：NM-KI-00087
验证数据：有

This R26-(CAG-Luc-EGFP) strain was generated by crossing R26-(CAG-LSL-Luc-EGFP)(NM-KI-190095) mice with Ddx4-Cre mice.

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R26-CAG-LSL-Luc-2A-EGFP

品系名：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Luciferase-2A-EGFP-wpre-polyA)Smoc
品系状态：活体 | 目录号：NM-KI-190095
验证数据：有

A CAG-LSL-Luciferase-2A-EGFP-wpre-polyA expression cassette was inserted at the Rosa26 locus site.

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hIL5-Tg(NMG,2)

品系名：NOD.Cg-PrkdcscidIl2rgem2Tg(hIL5)Smoc
品系状态：精子冻存 | 目录号：NM-KI-220131
验证数据：有

These transgenic mice carry humanized IL5.While hIL5-Tg(NMG)(Stock No.NM-KI-215005) mice function similarly to hIL5-Tg(NMG)(2) mice, for more detailed information please contact our technical advisor.

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R26-CAG-LSL-hHER2-IRES-Luc-2A-EGFP

品系名：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-2xpolyA-CAG-LSL-HER2-luciferase-EGFP)Smoc
品系状态：精子冻存 | 目录号：NM-KI-190008

A SA-2xpolyA-CAG-LSL-HER2-IRES-Luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the HER2 protein.

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R26-CreERT2

品系名：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA)Smoc
品系状态：活体 | 目录号：NM-KI-200041
验证数据：有

These mice harbor a SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA cassette in the Rosa26 locus generated by homologous recombination. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in multiple tissues after tamoxifen treatment.

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R26-pAPOE-hCYP3A4(FVB)

品系名：FVB-Gt(ROSA)26Sortm1(pAPOE-CYP3A4)Smoc
品系状态：胚胎冻存 | 目录号：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

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