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Models

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Mir29a/Mir29b-1-KO

品系名：C57BL/6Smoc-Mir29aemMir29b-1emSmoc
品系状态：胚胎冻存 | 目录号：NM-KO-220479

The Mir29a and Mir29b-1 gene were deleted to generate Mir29a,Mir29b-1 knockout mice.

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hOX40(2)

品系名：C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4) Smoc
品系状态：胚胎冻存 | 目录号：NM-HU-00078
验证数据：有

The exon1-5 and partial exon6 of endogenous mouse Tnfrsf4(Ox40) gene was replaced by the corresponding region of human TNFRSF4(OX40) gene. While hOX40(Stock No.NM-HU-00041) mice function similarly to hOX40(2) mice,for more detailed information please contact our technical advisor.

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Mycn-TRE-EGFP

品系名：B6;129S-Mycntm1(TRE-EGFP)Smoc
品系状态：胚胎冻存 | 目录号：NM-KI-00008

A TRE site and a loxp EGFP casette were inserted into introns 1-2 to create a Dox-inducible N-myc gene silence mice.

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Pnpla3-KO

品系名：B6;129S-Pnpla3tm1Smoc
品系状态：胚胎冻存 | 目录号：NM-KO-00051

Exons 1-3 and partial exon 4 were replaced by Neo cassette.

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Lyz2-Cre/Ncr1-2A-Cre/R26-LSL-hFCGR3A-tdTomato

品系名：C57BL/6Smoc-Ncr1tm2(2A-iCre)Lyz2tm1(cre)Gt(ROSA)26Sortm(SA-FRT-2xpolyA-CAG-FRT-loxp-stop-loxp-hFCGR3A-IRES-tdTomato-WPRE-polyA)Smoc
品系状态：精子冻存 | 目录号：NM-KI-220126
验证数据：有

Lyz2-Cre mice and Ncr1-2A-Cre mice(NM-KI-190027) were crossed with R26-LSL-FCGR3A (NM-KI-215052) to generate Lyz2-Cre/Ncr1-2A-Cre/R26-LSL-FCGR3A-tdTomato mice.

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hC5AR1/C5AR2

品系名：C57BL/6Smoc-C5ar1tm1(hC5AR1)C5ar2tm1(hC5AR2)/Smoc
品系状态：胚胎冻存 | 目录号：NM-HU-2000018
验证数据：有

The endogenous mouse C5ar1 and C5ar2 gene was replaced by human C5AR1 and hC5AR2 gene.

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hCSF1/hCSF1R(BALB/c)

品系名：BALB/cAnSmoc-Csf1tm2(CSF1)Csf1rtm3(hCSF1R)Smoc
品系状态：胚胎冻存 | 目录号：NM-HU-220016
验证数据：有

The endogenous mouse Csf1 and Csf1r genes was replaced respectively by human CSF1 and CSF1R genes.

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hOX40/hCTLA-4

品系名：C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4)Ctla4tm1(hCTLA4)/Smoc
品系状态：胚胎冻存 | 目录号：NM-HU-00105

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

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hIL2/hIL2RA(BALB/c)

品系名：BALB/cAnSmoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc
品系状态：胚胎冻存 | 目录号：NM-HU-220018
验证数据：有

The endogenous mouse Il2 and Il2ra gene was replaced respectively by human IL2 and IL2RA gene.

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hNKG2A/hCD94

品系名：C57BL/6Smoc-Nkg2tm1(hNKG2A)Cd94tm1(hCD94)/Smoc
品系状态：胚胎冻存 | 目录号：NM-HU-2000016

The endogenous mouse Nkg2 and Cd94 gene was replaced by human NKG2A and CD94 gene.

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