miR-31
多发性硬化
银屑
建立MicroRNA miR-31条件性敲除和转基因小鼠，揭示了微小RNA(microRNA, miR)-31在多发性硬化和银屑病发生发展中的作用及其分子机制，为自身免疫性疾病的治疗提供重要理论基础。这两篇研究成果同时在线发表在《Nature》子刊《Nature Communications》上，题目分别为“MicroRNA-31 Negatively Regulates Peripherally Derived Regulatory T Cell Generation by Repressing Retinoic Acid-Inducible Protein 3”和“NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis”。
