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PD-1&SEMA4D-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1)Sema4dem1(hSemA4D)/Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

This PD-1 and SEMA4D double knockin strain is established by crossing PD-1-HU and SEMA4D-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&GITR-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1) Tnfrsf18em1(hTNFRSF18)/Smoc Mutation Type: Humanization Research Application: Immune-related

This PD-1 and GITR double knockin strain is established by crossing PD-1-HU and GITR-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&CD40-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1)Cd40em1(hCD40)/Smoc Mutation Type: Humanization Research Application: Immune-related

This PD-1 and CD40 double knockin strain is established by crossing PD-1-HU and CD40-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&SIRPA-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1)Sirpaem1(hSIRPA)/Smoc Mutation Type: Humanization Research Application: Immune-related

This PD-1 and SIRPA double knockin strain is established by crossing PD-1-HU and SIRPA-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&TLR9-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1)Tlr9tm1(hTLR9)/Smoc Mutation Type: Humanization Research Application: Immune-related

This PD-1 and TLR9 double knockin strain is established by crossing PD-1-HU and TLR9-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

SIRPA&CD47&PD-1-HU Mouse

Strain Name: C57BL/6J-Sirpatm2(hSIRPA)Cd47em1(hCD47)Pdcd1em1(hPDCD1)/Smoc Mutation Type: Humanization Research Application: Immune-related

This SIRPA,CD47 and PD-1 triple knockin strain is established by crossing SIRPA-HU, CD47-HU and PD-1-HU mice of three humanized strains together. These triple double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&PD-L1&LAG3-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Lag3em1(hLAG3)/Smoc Mutation Type: Humanization Research Application: Immune-related

This PD-1,PD-L1 and LAG3 triple knockin strain is established by crossing PD-1-HU, PD-L1-HU and LAG3-HU mice of three humanized strains together. These triple double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&TIGIT&TIM3-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1)Tigitem1(hTIGIT) Havcr2em1(hHAVCR2)/Smoc Mutation Type: Humanization Research Application: Immune-related

Thi PD-1,TIGIT and TIM3 triple knockin strain is established by crossing PD-1-HU, TIGIT-HU and TIM3-HU mice of three humanized strains together. These triple double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Pdcd1-KO Mouse

Strain Name: C57BL/6J-Pdcd1em3Smoc Mutation Type: Knockout Research Application: Immune-related

The Pdcd1 knockout mouse model was generated by knocking out the exon2-4 region of the Pdcd1 using CRISPR/Cas technology.

Vsir-KO Mouse

Strain Name: C57BL/6J-Vsirem2Smoc Mutation Type: Knockout Research Application:

This Vsir knockout mouse model was generated by knocking out the exon 2-3 region of the Vsir gene   via CRISPR/Cas mediated recombination.

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