Welcome

Filter:

pd-1

Mouse

Citations

Vsir-KO Mouse

Strain Name: C57BL/6J-Vsirem2Smoc Mutation Type: Knockout Research Application:

This Vsir knockout mouse model was generated by knocking out the exon 2-3 region of the Vsir gene   via CRISPR/Cas mediated recombination.

PD-1&CD3e-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1) Cd3eem1(hCD3E) /Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

This PD-1 and CD3e double knockin strain is established by crossing PD-1-HU and CD3e-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&CD27-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1) Cd27em1(hCD27) /Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

This PD-1 and CD27 double knockin strain is established by crossing PD-1-HU and CD27-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

VISTA-HU Mouse

Strain Name: C57BL/6J-Vsirem2(hVSIR)/Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

The exon 2-3 of endogenous mouse Vsir gene was replaced by the exon 2-3 of human VSIR(VISTA) gene .

PD-1&4-1BB-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1)Tnfrsf9em1(hTNFRSF9)/Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

This PD1 and 4-1BB double knockin strain is established by crossing PD1-HU and 4-1BB-HU mice  together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&PD-L1&OX40-HU Mouse

Strain Name: C57BL/6-Tnfrsf4em3(hTNFRSF4)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

This PD1 ,PD-L1 and OX40 triple knockin strain is established by crossing IDO1-HU, PD1-HU and CTLA4-HU mice of three humanized strains together. These triple double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&PD-L1&IDO1-HU Mouse

Strain Name: C57BL/6-Ido1tm1(hIDO1)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc Mutation Type: Humanization Research Application: cancer research,Immunotherapy,drug screening

This PD1 , IDO-1 and CTLA4 triple knockin strain is established by crossing IDO1-HU, PD1-HU and CTLA4-HU mice of three humanized strains together. These triple double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&PD-L1-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1)  Cd274em1(hPD-L1)/Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

These  mice are PD1 and  PD-L1 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&TIM3-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1)  Havcr2em1(hHAVCR2)/Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

These  mice are PD1 and  TIM3 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

PD-1&LAG3-HU Mouse

Strain Name: C57BL/6J-Pdcd1em1(hPDCD1) Lag3em1(hLAG3)/Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

These  mice are PD1 and LAG3 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Contact us Email Gene-editing proposal Gene-editing proposal Back to top Back to top