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U-GEMMs

About 322 results
Mice

hLAG3

Strain Name：B6.129S-Lag3tm1(hLAG3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00049

The endogenous mouse Lag3 gene exon1-7 was replaced by human LAG3 gene extracellular region by homologous recombination.

Mice

hSLAMF7

Strain Name：C57BL/6Smoc-Slamf7em(hSLAMF7)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18028

The endogenous mouse Slamf7 gene was replaced by human SLAMF7 gene .

Mice

hHLA-A2

Strain Name：C57BL/6Smoc-H2-D1em1(hHLA-A2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-204988

The endogenous mice H2-D1 gene was replaced by human HLA-A2 gene.

Mice

hHLA-A11

Strain Name：C57BL/6Smoc-H2-K1em1(hHLA-A11)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-204987

The endogenous mice H2-K1 gene was replaced by human HLA-A11 gene.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hLAG3(BALB/c)

Strain Name：BALB/cAnSmoc-Lag3em1(hLAG3)/Smoc
Strain State：Developing | Cat. NO.：NM-HU-2000051

The endogenous mouse Lag3 gene was replaced by human LAG3 gene.

Mice

hHLA-DPB1*04: 01

Strain Name：C57BL/6Smoc-H2-Ab1em1(hHLA-DPB1*04: 01)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210011

The endogenous mice H2-Ab1 gene was replaced by human HLA-DPB1*04:01 gene.

Mice

hHLA-E

Strain Name：C57BL/6Smoc-Igs2em1(hHLA-E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200221

The endogenous human HLA-E gene (about 11kb) was knocked into the H11 locus via CRISPR/Cas9 mediated recombination.

Mice

hLAIR1/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Lair1em2(LAIR1)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220040

hLAIR1(NM-HU-2000011)，hPD-1(NM-HU-00015) and hPD-L1(NM-HU-00062) were crossed tegother to generate hLAIR1/hPD-1/hPD-L1 mouse.

Mice

hHLA-DPA1*03: 01

Strain Name：C57BL/6Smoc-H2-Aaem1（hHLA-DPA1*03: 01）/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210009

The endogenous mice H2-Aa gene was replaced by human HLA-DPA1*03: 01 gene

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