Gene-editing proposal
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Disease：Carcinoma Organisms.：Human
F12 NUTRIENT MIX- KAIGHNS MOD（Invitrogen,21127022）+ 10%FBS
Disease：Carcinoma Organisms.：Human
F12 NUTRIENT MIX- KAIGHNS MOD（Invitrogen,21127022）+ 10%FBS
Disease：Carcinoma Organisms.：Human
F12 NUTRIENT MIX- KAIGHNS MOD（Invitrogen,21127022）+ 10%FBS
Our own-developed M-NSG mice used the CRISPR/Cas9 technique to knock out both Prkdc and Il2rg genes from NOD mice to obtain severely immunodeficient mice. These mice lack mature T, B, and NK cells and are an important carrier for humanized mice, xenografts, and immune reconstitution. They also have significant values for the study on human hematopoietic stem cells, tumorigenesis and tumor treatment, immunodeficiency diseases, and immune mechanisms in the body.
The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies. Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.
Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.