Strain Name: B6.129-Appl1tm1(flox)Smoc Mutation Type: Conditional knockout Research Application:
These mice carry loxP sites flanking exon 5 of Appl1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of this gene.
Strain Name: C57BL/6J-Degs2em1Smoc Mutation Type: Knockout Research Application: Therapeutic antibody target
Using CRISPR/Cas9 technology, exon 2 of Degs2 gene was deleted to generate Degs2 knockout mice.
Strain Name: C57BL/6J-Il11em1Smoc Mutation Type: Knockout Research Application: Immune-related
This Il11 knockout mouse model was generated by knocking out the exon 2-4 region of the Il11 using CRISPR/Cas technology.
Strain Name: C57BL/6J-Kir3dl2em1Smoc Mutation Type: Knockout Research Application: Therapeutic antibody target
Using CRISPR/Cas9 technology, exon 3-7 of Kir3dl2 gene was deleted to generate Kir3dl2 knockout mice.
Strain Name: C57BL/6J-Gt(ROSA)26Sorem1(SA-LSL-Notch1C-IRES-nEGFP)Smoc Mutation Type: Knock-in Research Application: Spontaneous tumor model
These mice harbor a SA-LSL-Notch1C-IRES-nEGFP cassette in the Rosa26 locus generated by homologous recombination.Notch1C (mouse Notch1 ,amino acids 1749–2293)